United States. United States. Territories.pH-driven conformational switching of engineered metal binding sites of the lanthanide proteins.
Gd- and Eu-binding sites of the metalloproteins Lm and Lk were engineered by the conjugation of a tris(2-aminoethyl)amine-terminated (T(3)A) peptide onto a lysine residue in the protein using a bioinorganic synthetic approach. These novel metal binding sites retain the metal binding ability of the natural metalloprotein and show pH-dependent conformational switching in aqueous solution in the range pH 6-11. The switching of the metal binding sites in the protein occurs on a time scale of days, making the complexes useful for the fabrication of functional materials. The unique pH-dependent behavior of these metal binding sites and the possibility of detecting and separating these complexes from a mixture using magnetic susceptibility makes them attractive candidates for development of biosensors and other technologies.Implementing a modular telehealth system for the care of patients with heart failure: A qualitative study.
Heart failure (HF) is a condition that is associated with high morbidity and mortality and imposes a significant economic burden on society. To meet the needs of the growing number of patients with HF, regional HF care must become more standardized and efficient. Telehealth, which entails the use of technology to provide clinical care, may provide such an opportunity. The purpose of this study was to understand the health-care providers' experiences using telehealth in HF care. A thematic qualitative analysis approach was used. Semistructured interviews were conducted with six HF care providers across the inpatient and outpatient telehealth program sites. A member check and peer debrief were performed to check and improve the coding of the data. Content analysis was used to identify the themes within the data. Themes included establishing the program, achieving professional care, developing a foundation for collaboration, providing a framework for care, and enhancing patient care. The data supported a clear preference for telehealth over traditional care, regardless of their status. Telehealth was found to help fill gaps in service and allowed providers the ability to address patient needs immediately and asynchronously. Challenges related to continuity of care, availability of services, and patient factors affected the uptake and implementation of telehealth. Telehealth is an important strategy for standardized, regional HF care. Implications for Rehabilitation The growing number of patients with HF and the associated burden of the condition on society is placing
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